SkinCeuticals P-TIOX Wrinkle-Modulating Peptide Serum (2-Pack Value Set)
Includes two P-TIOX peptide serums for advanced wrinkle and texture correction.

Includes two P-TIOX peptide serums for advanced wrinkle and texture correction.
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How to use
Key ingredients
Key benefits
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Reviews (1269)
I've been a user of SC's CE Ferulic, retinol, moisturizers, and sunscreens for awhile now, and while I find all of their products effective, this has been the holy grail for my skin. Within a week of use my skin was GORGEOUS. Glowy, clear, tighter. I even had a reduction in breakouts (which was not the case with the CE, which took me about 3 weeks to adjust to) and my fine lines were less visible. Every time I put on this serum, I felt like I was applying a real-life filter to my face. I pray to the skin gods that this product continues forever. And this review: totally and completely unincentivized. I LOVE THIS PRODUCT! For reference, age: 42; skin type: dry, environmental factors: live in a high-altitude environment which dries skin easily; skin is generally sensitive and red (have never been able to progress to daily retinol and am still on .3) but tolerant of most products. No injectables or fillers yet. I just wish I had a before and after photo to share.
I use it morning and night and love it. How can I tell that it makes a difference? I regularly get complements from family and friends โฆ โwow, your skin looks amazing!โ. It gives me a youthful glow. I use it in the morning after C E Ferulic and before Emolience, and in the evening after Glycolic 10 and before Triple Lipid. Itโs a routine that Iโve been persistent with for years and I really think its kept my skin looking amazing.
I definitely noticed a purge at first but expected this as certain routines that work hard on your skin will do this. After the first week my skin readjusted and I started to notice a more glow and so did others! It softened down some of the deep wrinkles but it didn't seem to help much with my eye crowd feet. It helped with my 11 lines and my smile wrinkles though! It didn't dry out my skin or cause any burning. The product was easy to spread and a little bit goes a long way. The dropper made it easy to apply just the right about to my clean hands and then massage into my skin. I followed up with a lotion and sunscreen as recommended!
This has been one of the best serums I've used in a while in regards to my fine lines around my eyes, mouth, and forehead. I feel like this serum is a little thicker and stays in place better when applying it to those areas.
Love this line. Tried this one and noticed a difference after one use. I felt my skin tighten and radiate after one night. I will continue to use this serum. Left my skin feeling radiant.
Iโm not sure how, but this serum did have my skin looking glassy that very first week. My skin has never looked better and Iโm only half way through the bottle. Here again is another Skinceuticals product I wonโt be able to live without.
Just purchased my 2nd bottle. I have used this product for about 3 months in conjunction with CE Feurlic and HA Muli Glycan. I am very happy with the results so far and only use it once a day.
I was lucky enough to be asked to give an opinion on this P-TIOX facial serum. I truly believe in a good facial routine. Finding the right products for your face makes the distance between young looking beautiful skin and dry dull looking skin. I have used many high end/expensive serums with mixed results. I have however truly loved several and I would out this in that same category. You don't have to use very much at a time and you notice a difference almost immediately. I was thrilled with the results within the first week but took a decent amount of time before giving a review just to be sure. My skin is now hydrated, balanced, and soft. My skin looks and feels younger. It also works well with my moisturizer under my foundation (I use Chanel) without any pilling. This product is worth the money and I would recommend it to a friend or family member without hesitation.
I've been using Skinceuticals P-TIOX Peptide Serum for a few weeks now, and I'm really impressed with the results. The most noticeable improvement has been in the expression lines on my foreheadโthey are significantly reduced, giving my skin a smoother, more youthful appearance. I did experience a mild reaction under my eyes at first, but it cleared up quickly once I stopped applying the serum to that area. Overall, this serum has been a fantastic addition to my skincare routine, and I love the difference it's made!
I have been a fan of SkinCeuticals and have used their vitamin C serum for years. So I was excited to try this new product. One thing I trust about this brand is that they put a lot of thought and research into their products. I have been using P-Tiox for several weeks now and have noticed in improvement in the texture of my face and in improvement on my wrinkles and fine lines. I am still using this with the vitamin c serum. And I'm really impressed with the results. I would recommend this to everyone.
I received this product a few months ago for free and was super excited to try it. I am a big fan of Skinceuticals already and a lot of aestheticians in Scottsdale use their line. The P-Tiox is a serum, that you use 2x daily. It took a few weeks to really notice the difference, but I really started to see my skin smoothing out in about 3-4 weeks especially smile lines and forehead. I will definitely order this product again and keep in my regimen.
This product is amazing! Highly recommend! Clear skin lines, Botox in a bottle.
I received this product from skinceuticals free in exchange for my honest review, it has a serum texture that absorbs quickly into the skin and layers well with other skincare products. Its main star ingredients are two peptides - hexapeptide and dipeptide that work together to reduce expression lines all over the face. Its main supporting ingredients include PHA, Niacinamide, and laminaria extract that provide hydration and gentle exfoliation to leave your skin radiant and renewed. I haven't experienced any irritation while using and have already begun to notice a marked difference in my nasolabial folds and the small lines between my eyebrows. I'm super excited to see what continued use will do for these lines as they're my most prominent ones so far. I hope it will prevent the classic horizontal forehead lines from appearing in the future as well. It's gentle enough to use twice daily but if you use it in the morning make sure to follow it up with a moisturizer and most importantly sunscreen! The only thing negative I have to report is the price - as this product is out of the price range of those with lower incomes. However, its effectiveness makes it worth saving for and I believe this bottle with last me a couple months at minimum. Overall, I highly recommend.
Thanks you Bzzagent for the product, it was amazing. Super light and airy serum that goes on smoothly. Noticed my skin got tighter and brighter after using it for only one week. I would highly recommend.
I am 51 years old, I get BOTOX and pillars. After using this for 2 months I might not have to get them again. This stuff is absolutely amazing my skin feels entirely healthy my wrinkles are fading. Spend the money on this for yourself you won't be disappointed!
I would use this product every morning and night and within a few days I could visibly notice a difference in the appearance of my fine lines and wrinkles. I will continue to use this product and purchase again. It was a perfect and much needed addition to my skin care routine.
Definitely needs to be used multiple days/weeks in a row to see results, but my skin seemed smoother after the 21-day trial!
My skin has been absolutely radiant since using this. Not sure if it's done much for my forehead lines, but my crow's feet seem to be more faint. And my skin has been soo plump and glowy over the past month. Glass skin in a bottle for sure. Price is steep though and I was given this in exchange for a review. This product is absolutely lovely but not necessarily a holy grail worth the price of admission.
I'm an avid skinceuticals shopper. Their vitamin C serum, eye creams, and moisturizers are my holy grails and I have no problem spending the $$$ on hem because they work. So I was very excited to try the P-TIOX. The serum sinks in beautifully, no weird smells, no stickiness - just made my skin look smooth, soft, glowy. It took a few weeks to see the results as stated by Skinceuticals but wow! Worked as stated. WILL ABSOLUTELY buy this again and again.
I love skincuticles, my skin has been a lot firmer and brighter within weeks. This has become a stable in my routine, if you have mature skin, you need this ,
I have been using this product during my nighttime routine to fight fine lines on my forehead and between my eyebrows. I was pleased by how nice the serum felt; it absorbs nicely, makes my skin feel hydrated, and seems very gentle on my sensitive skin. I have been using this for around a month and have seen a decrease in the visibility of the fine lines on my forehead, which was my goal! I can't ask for much else from a skincare product, it is effective and still gentle. I have struggled with more aggressive products like retinol that leave my skin dry, irritated, and damaged, so this is a great and effective product for me that avoids all the headaches that come with many other solutions I've tried.
This serum is so amazing! I've been using it after I apply my CE Ferulic serum in the mornings and after my sunscreen and I can already tell a difference in my skin elasticity. I have no lines around my eyes and I feel like the serum works hand in hand with my Botox in my forehead. The texture is very liquid, which I like, since it makes it very easy to spread and a little goes a really long way. I can't wait to see the results after using this serum for even longer.
I'm really enjoying this non-invasive alternative to Botox. The peptide serum has noticeably diminished my expression lines and my skin looks remarkably radiant. I've been hesitant to try injectables, so this is the ideal solution for me. My expression lines have never been too pronounced, and this serum works perfectly for them.
Just entered my 40s with a toddler and I need products that do what they say without a lot of fuss. This serum is easy to apply, doesn't leave my face feeling uncomfortable (not sticky, not oily, not super dry), and does seem to keep wrinkles at bay as long as I continue using it. I used it for a little over a week and then forgot to bring it on our beach trip for 5 days. I could definitely tell a difference. My main concern is a couple wrinkles on my forehead and they were more pronounced by the time we got back from our trip. Now I use it each night and the wrinkles are fading.
Now in the 40s wrinkles getting settle in and skin is sagging, but I concern dull and uneven skin tone the most because that shows age on my face of all. After using the serum for a month, the wrinkles getting less noticeable but the best change is clarified skin tone and subtle glow that erase ages on my face. Completely satisfied. I had no idea I even wanted this result on my skincare now I know definitely.
I'm upfront with every review i write. I took a little longer the submit my review. I wanted to make sure i tried it for awhile and actually liked it. After 3 weeks I've noticed a difference. After applying the serum my face feels more firm. I'm super self conscience about my face. I'm 38 and i don't have as much elasticity, however using this after about three weeks you too will notice results. Try it out, you'll like it.
I have been using this product for the last 40 days and I can't rave enough about what this serum did for my skin. I normally have a lot of redness in my face mainly around my checks and above my jaw. I used this serum as a part of my nighttime routine and I've never looked so hydrated and refreshed. The redness has noticeably calmed down. I love how moisturizing it is without feeling oily. It gives the appearance of glass skin. I also noticed slight change in minor smile lines. Less creasing around the eyes. I mainly used this serum at night and I wouldn't recommend using it for all day as again it is very moisturizing that it could be heavy for everyday use under makeup.
I have been using P-TIOX for the past six weeks and I noticed a huge difference on my fine lines and my overall skin texture. The serum absorbs really well and does not have fragrance (which I appreciate so much!). I have been applying the product as follows: three drops in the am and three drops in the evening -A little goes a long way. It is not greasy or heavy and can be layered with a heavy moisturizer. I know it is on the pricey side, but it is so worthy. I am on my mid-forties so I see skin care as an investment. Disclosure: I received this product in exchange of my honest review.
I've been using this product twice daily - four drops all over the face. I do have a pretty well-aging routine that includes Tretinoin but I have noticed a slight radiance after using this product for a month. It comes in a no frill dropper bottle. The serum itself is pleasant to use - it's lightweight yet add a nice layer of hydration. It playes well with my other toners/serums. I'm excited to see more results from it!
I have been using P-TIOX every morning for 30 days and I can see that my 11 lines are less noticeable. I am so happy to have found an alternative to getting Botox as I am afraid of needles.
I love this serum, it's very light weight and absorbed very quickly with feeling greasy and sticky, it gives my skin beautiful glow and hydration.
This product sinks into skin on contact making it look and feel well moisturized and smooth. I recently got Botox and this serum is a great complement to it. Since using the serum, my skin does appear more radiant and clear. I'm definitely going to keep using it.
I was impressed at the quality of this serum! You can feel it being absorbed as soon as you apply it. I loved that it doesn't simply sit on skin like other brands that I've tried. I thought it did great work on my fine lines and wrinkles! It seemed to plump my skin and even out my textured skin over the course of just 30 days. I love the way my skin looks now- tighter and brighter! Thank you P-TIOX.
This product is brilliant! I've been using it for sometime now and noticed drastic improvements on my skin. I do Botox once a year but with this product I may delay it -cause skin is tighter, even and lines are definitely less visible. Love the packaging perfect to take it with me everywhere I go- just several drops twice a day do a magic for me-so I highly recommend it to everyone.
I am totally in love with the SkinCeuticals P-Tiox serum. It quickly absorbed into my skin and appears to have reduced the fine lines around my eyes and around my mouth. I have sensitive and acne prone skin and this did not cause any kind of breakouts. I also noticed an improvement in my overall skin texture and my skin have never looked better. Thank you SkinCeuticals!
After using this for a few weeks, I have noticed a change in my skin. There is less texture. My skin definitely looks more hydrated. I've also had a few compliments and people asking me what I've been doing to my skin lately.
Since receiving this serum, I have used it 2X a day everyday. I just say, a little goes a long way. It applies smooth and easily. My skin absorbs it well. I have noticed that it does help with my fine lines as well. Definitely do not skip out on this serum, add this to your skincare routine now!
Great product and saw results almost instantly. Definitely we will repurchase at my local .
I am the medical director of a MediSpa and have tried most products on the market. p-tioxx def outperforms similarly marketed peptide serums. I have been using a sample for the past 5 months in conjunction with neurotoxin- wrinkles gone and the glass skin is a reality!
The product itself is great but the actual company is the worst company I have ever shopped with. They are a fraud. They tell you to spend a lot of money online and tell you they will give you hundreds of dollars in gift with purchase and once you hit that purchase button, they take the gift with purchase off.











